Sympathetic activation in chronic renal failure.
نویسندگان
چکیده
The potential involvement of sympathetic overactivity has been neglected in this population despite accumulating experimental and clinical evidence suggesting a crucial role of sympathetic activation for both progression of renal failure and the high rate of cardiovascular events in patients with chronic kidney disease. The contribution of sympathetic neural mechanisms to the occurrence of cardiac arrhythmias, the development of hypertension, and the progression of heart failure are well established; however, the exact mechanisms contributing to heightened sympathetic tone in patients with chronic kidney disease are unclear. This review analyses potential mechanisms underlying sympathetic activation in chronic kidney disease, the range of adverse consequences associated with this activation, and potential therapeutic implications resulting from this relationship.
منابع مشابه
Characterization of a rat model of moderate chronic renal failure--focus on hematological, biochemical, and cardio-renal profiles.
The pathophysiological modifications underlying chronic renal failure seems to be dependent on the insufficiency degree, which will determine the moment to start therapy. As there is yet limited information about animal models of moderate chronic renal failure, we intended to perform a complete characterization of the hematological and cardio-renal alterations induced by partial nephrectomy. Bl...
متن کاملNervous System Early Sympathetic Activation in the Initial Clinical Stages of Chronic Renal Failure
Direct and indirect indices of neuroadrenergic function have shown that end-stage renal disease is characterized by a marked sympathetic overdrive. It is unknown, however, whether this phenomenon represents a peculiar feature of end-stage renal disease or whether it is also detectable in the early clinical phases of the disease. The study has been performed in 73 hypertensive patients, of which...
متن کاملEarly sympathetic activation in the initial clinical stages of chronic renal failure.
Direct and indirect indices of neuroadrenergic function have shown that end-stage renal disease is characterized by a marked sympathetic overdrive. It is unknown, however, whether this phenomenon represents a peculiar feature of end-stage renal disease or whether it is also detectable in the early clinical phases of the disease. The study has been performed in 73 hypertensive patients, of which...
متن کاملRenal Denervation for Chronic Heart Failure: Background and Pathophysiological Rationale
The activation of the sympathetic nervous system is associated with cardiovascular hospitalizations and death in heart failure. Renal denervation has been shown to effectively reduce sympathetic overdrive in certain patients with uncontrolled hypertension. Pilot trials investigating renal denervation as a potential treatment approach for heart failure were initiated. Heart failure comorbidities...
متن کاملSympathetic activation in chronic kidney disease: out of the shadow.
Chronic kidney disease (CKD) is a global and growing health problem. In the United States alone, an estimated 20 million people are affected by CKD, equating to 13% of the adult population.1 While carrying an increased risk for the development of end-stage renal disease (ESRD), the major threat to patients with CKD is the associated morbidity and mortality from cardiovascular causes, which is u...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Journal of the American Society of Nephrology : JASN
دوره 20 5 شماره
صفحات -
تاریخ انتشار 2009